Inventions
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Active Delivery and Flow Redirection: novel devices and method of delivery of materials to patients.
Date Filed: U. S. Application No. 11/434,080 filed May 15, 2006.
Summary: Intraparenchymal catheters generally deliver infusate in an spheroidal volume expanding from the catheter shaft. Applications that require delivery over the entire area of the thin cortical sheet would demand an unacceptable number of catheters, with unacceptable loss of infusate in non-cortical matter. This invention discloses a device that would allow such a delivery with a single catheter and a single port of entry. Other devices utilizing the ventricular clearance to distribute infusate through circumventricular organs is also disclosed.
Status: Device prototypes were constructed and ex-vivo tests with positive results conducted under a Phase I SBIR grant from the NIH.
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Active Delivery and Flow Redirection: novel devices and method of delivery of materials to patients.
Date Filed: International Application filed May 14, 2007.
Summary: Software planning in conjunction with the devices disclosed above was added to this international filing.
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A treatment simulator for brain diseases and method of use therof.
Date Filed: U. S. Application No. 60/938,863 filed May 18, 2007.
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Device, methods, and control of sonic guidance of molecules and other materials using time-reversal acoustics.
Date Filed: U. S. Provisional Application No. 61/125,210 filed April 23, 2008.
Summary: Acoustic waves exhibit a so-called streaming force that pushes objects along the direction of sound propagation. Precise motions require well-focused beams. The technique of time-reversal acoustics (TRA) overcomes beam distortions introduced by propagation along irregular paths to focus sound without knowledge of the medium properties. TRA requires a small receiver to be placed at a point of desired focus. The invention refines TRA by introducing unique and efficient interpolation technologies allowing large regions to be irradiated with well-focused acoustic beams and with no receiver at a desired point of focus. Applications include intraparenchymal delivery, removal of contaminants in environmental applications, retrieving oil in stuck underground pockets, etc.
Status: Research to verify streaming in gel surrogates of tissue is underway. After proof of principle, interpolation will then be tested. It is then planned to seek government grant funding.
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Device and method for delivering therapeutic agents to an area of the body.
Date Filed: U. S. Application No. 12/152,280 filed May 13, 2008.
Summary: This device is a minimally invasive single lumen system capable of delivering an agent to multiple tissue channels either individually or simultaneously without inducing bubbles into the infusate.
Status: Device prototypes were constructed and ex-vivo tests with positive results conducted under a grant from the Kinetics Foundation
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Valve catheter
Date Filed: Provisional US Application#61/097,425 filed September 16, 2008
Summary: This device is an intra tissue catheter that does not clog on insertion.
Status: Prototypes produced and tested extensively in gels, Animal testing has just commenced.
Summary: The overall goal of this invention is to improve the outcome, and reduce the toxicity, for patients with primary and with metastatic brain tumors. This it seeks to accomplish by providing critical information on (i) the entry, the concentrations, and the total dose of systemically administered chemotherapy drugs into central nervous system (CNS) neoplasms, (ii) the likely routes of tumor dissemination, and (iii) quantifiable data on brain edema and intracranial pressure. Applications on drugs for essentially any other neurological disease, or for chemotherapies for systemic disease, are also disclosed.
Status: Prototypes are being constructed and demonstrated at upcoming meetings. Negotiations are underway with industry for licensing applications.